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Isem tal-Prodott:
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2 - amino - n- (2-chloro-6-methylphenyl) thiazole-5-carboxamide |
| Sinonimi: |
2 - amino - n- (2-chloro-6-methylphenyl) -1,3-thiazole-5-carboxamide98%; dasatinibimperity2; 2 - amino - n- (2-chloro-6-methylphenyl) thiazole-5-carboximide); 2-amino-5 - [(2-chloro-6-methylphenyl) carbamoyl] -1,3-thiazole; 2 - amino - 5 - [(6-chloro-o-tolyl) carbamoyl] -1,3-thiazole; 5 - ThiazoleCarboxamide, 2 - amino-n- (2-chloro-6-methylphenyl); dasatinibintn-2; 2 - amino - n - (2 - chloro-6-meth; 2-amino-n- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide; |
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CAS:
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302964-24-5 |
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MF:
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C11H10CLN3OS |
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MW:
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267.73 |
| Einecs: | 1806241-263-5 |
| Punt tat-togħlija | 362.0 ± 37.0 grad (previst) |
| Punt ta 'tidwib | 208.0 sa 212.0 grad |
| Densità | 1.474 ± 0.06 g / cm³ (imbassar) |
| Koeffiċjent tal-Aċidità (PKA) | 11.09 ± 0.70 (previst) |
| Solubilità | Solubbli fid-DMSO (ammont żgħir), metanol (ammont żgħir) |
| Forma | Trab tal-kristall |
| Kulur | Abjad sa isfar ċar għal oranġjo ċar |
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Temp tal-Ħażna.
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Żomm il-kontenitur magħluq sewwa. Aħżen f'post frisk u skur. |
Użu
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Użi
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Dasatinib huwa inibitur qawwi ta 'oncokinase orali li jista' jinibixxi oncokinases multipli bħal BCR - ABL kinase u kinases tal-familja SRC. Klinikament, huwa użat għat-trattament tal-kromożoma ta 'Philadelphia - pożittiv (ph +) lewkimja majelojde kronika (CML) u l-kromożomi ta' Philadelphia {- pożittiv (ph +) lewkimja limfoblastika akuta (kollha) f'pazjenti li huma reżistenti għal jew intoleranti ta 'Imatinib Mesylate.in żieda Fuq 2 - amino - n- (2-chloro-6-methylphenyl) thiazole-5-carboxamide ġew murija fi studji li għandhom attività inibitorja eċċellenti ta 'ABL kinase u attività antineoplastika. Dawn il-komposti jistgħu jiġu żviluppati aktar fi mediċini antineoplastiċi ġodda għat-trattament tal-mard ikkawżat minn disfunzjoni tat-tyrosine kinase, bħal lewkimja majelojde kronika (CML), kanċer gastriku, u tumuri stromali gastro-intestinali (GISTs). |
It-tags Popolari: 2 - amino - n- (2-chloro-6-methylphenyl) thiazole-5-carboxamide CAS No.:302964-24-5, iċ-Ċina, manifatturi, fornituri, fabbrika, drawwa, bl-ingrossa.
