BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID Informazzjoni bażika
| Isem tal-Prodott: | BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENIL)-BUTYRIC ACID |
| Sinonimi: | Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,(bR)-;(R)-Sitagliptin N-Boc-Acid IMpurity;Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid (3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid;Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid, >=99%;(3R)-N-Boc-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid;(3R)-N-(tert-Butoxycarbonyl) )-3-aMino-4-(2,4,5-trifluorophenyl)-butanoic acid- Boc-(R)-3-AMino-4-(2,4,{ {25}}trifluorofenil) butanoic acid (BOC acid);[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-(R)-benzenebuta; BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENIL)-BUTYRIC ACID |
| CAS: | 486460-00-8 |
| MW: | 333.31 |
| MF: | C15H18F3NO4 |
| EINECS: | 691-120-8 |
BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID Proprjetajiet Kimiċi
| Punt tat-tidwib | 136-138 grad |
| Punt tat-togħlija | 443.1±45.0 grad (Imbassar) |
| densità | 1.292±0.06 g/cm3(Imbassar) |
| temperatura tal-ħażna. | 2-8 grad |
| solubilità | Kloroform (ftit), DMSO (ftit), aċetat ta' etil (ftit), metanol (ftit) |
| forma | Solidu |
| pka | 4.30±0.10(Imbassar) |
| kulur | Abjad għal Off-White |
BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID Użu U Sintesi
| Forma Fiżika | Abjad għal Isfar Solidu |
| Deskrizzjoni | Boc-(R) -3-amino-4 -(2,4, 5-trifluorophenyl) butyric acid huwa intermedjarju importanti għall-preparazzjoni ta' sitagliptin. Sitagliptinphosphate huwa l-ewwel inibitur tad-dipeptidase -IV(dpp-4) approvat mill-FDA fl-2006. Jintuża għat-trattament tad-dijabete mellitus tat-tip II. Għandu effett ipogliċemiku ovvju meta jintuża waħdu jew flimkien ma 'metformin u pioglitazone, u huwa sikur li jittieħed, tollerat tajjeb, bi ftit reazzjonijiet avversi. |
| Użi | (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid intuża bħala reattiv għall-preparazzjoni ta' dipeptidyl peptidase{{6 }} (DPP4) inibituri għat-trattament tad-dijabete tat-tip 2, bħal sitagliptin. |
It-tags Popolari: boc-(r)-3-amino-4-(2,4,5-trifluoro-phenyl)-butyric acid cas nr.486460-00-8, iċ-Ċina, manifatturi, fornituri, fabbrika, użanza, bl-ingrossa
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