Informazzjoni bażika
|
Isem tal-Prodott: |
11-alpha-Hydroxycarvenone |
|
Sinonimi: |
(11a,17a)-11,17-Dihydroxy-3-Oxo-Pregna-4,6-Diene-21-Aċidu Karbossiliku;3- (3-oxo-11a,17ss-Dihydroxy-4,6-Diene-Pregna-17a-yl)Propanoic Acid Lactone |
|
CAS: |
192569-17-8 |
|
MF: |
C22H28O4 |
|
MW: |
356.46 |
|
EINECS: |
606-276-4 |
Proprjetajiet fiżiċi u kimiċi
|
Punt tat-tidwib |
232-234 grad |
|
Densità |
1.25 |
|
Temperatura tal-ħażna. |
-20 Grad Freezer |
| Dehra | Solidu kristallin isfar |
Użu
|
Deskrizzjoni |
Mediċini kontra l-pressjoni għolja, materja prima farmaċewtika jew intermedji ta 'eplerenone. |
Serje ta' derivattivi utli tal-canrenone jistgħu jinkisbu minn 11 -canrenone idrossilat. Ibbażat fuq l-użu ta 'trasformazzjoni mikrobjali biex tikseb 11 -canrenone hydroxylated, GDSearle fl-Istati Uniti kiseb epleren antagonist ta' riċettur ta 'aldosterone sterojdi selettiv ġdid wara sitt (jew seba') sintesi kimika. Ketoni ġew approvati mill-FDA f'April 2002, u ġew elenkati fl-Istati Uniti minn Pharmacia fl-2003. Studji kliniċi sabu li meta mqabbla ma 'Canrenone u Spironolactone fit-trattament ta' mard kardjovaskulari bħal pressjoni għolja, Eplerenone naqqas b'mod sinifikanti l-effetti sekondarji u b'mod sinifikanti naqqas il-mortalità ta' insuffiċjenza tal-qalb.
It-tags Popolari: 11-alpha-hydroxycarvenone cas no.192569-17-8, iċ-Ċina, manifatturi, fornituri, fabbrika, użanza, bl-ingrossa
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